In the U.S., Juvéderm™ injectable gel is indicated for injection into the mid to deep dermis for correction of moderate to severe facial wrinkles and folds such as nasolabial folds.

The key ingredient of Juvéderm is hyaluronic acid which is a naturally occurring, biodegradable complex sugar found in the human body and in all living animals. Among other things, hyaluronic acid hydrates the skin and adds volume, contributing to the overall appearance of the skin.

As we age, the ability of cells to produce hyaluronic acid diminishes, often resulting in facial wrinkles and folds as the skin loses volume. Juvéderm is administered in small doses by intradermal injection directly into wrinkles and folds, such as nasolabial folds, temporarily filling and augmenting the treated area.

The U.S. Food and Drug Administration has approved 2 formulations. Juvéderm Ultra, is a highly cross-linked formulation for more versatility in contouring and volumizing of facial wrinkles and folds. Juvéderm Ultra Plus, is a more highly cross-linked robust formulation forvolumizing and correction of deeper folds and wrinkles.

Risks and side effects:

The most commonly reported side effects are temporary injection site redness, swelling, pain/tenderness, firmness, swelling, lumps/bumps, and bruising. Exposure of the treated area to excessive sun, and extreme cold weather should be minimized until any initial swelling and redness has resolved. If laser treatment, chemical peel or any other procedure based on active dermal response is considered after treatment with Juvéderm™ injectable gel, there is a possible risk of an inflammatory reaction at the treatment site. Juvéderm Implants should not be used in patients with severe allergies and a history of anaphylaxis or in patients with allergies to bacterial proteins.

Source: Allergan

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